Table of Contents

1. Introduction
2. Neutralizing Antibodies
3. Principle of the Rapid Test
4. Procedure of the Test
5. Accuracy and Reliability
6. Immuno Company Solutions
7. Conclusion
8. References

Introduction

The rapid test for neutralizing antibodies developed in China is designed to provide quick insights into the presence of antibodies that block virus infection. This test is especially relevant in the context of the COVID-19 pandemic, where rapid and accurate detection of neutralizing antibodies is crucial for understanding immunity levels in populations.

Neutralizing Antibodies

Neutralizing antibodies are a specific class of antibodies that interfere with the biological activity of pathogens, such as viruses, by binding to them and preventing their entry into host cells. These antibodies are critical indicators of immune protection.

Principle of the Rapid Test

The rapid test employs a lateral flow assay format, utilizing colloidal gold or fluorescence markers to visualize results. When a sample (e.g., blood or serum) is applied, antibodies in the sample bind to antigens pre-coated on the test strip. The presence of a control line ensures the test is working properly, while a test line indicates the presence of neutralizing antibodies.

Procedure of the Test

The typical procedure for conducting a neutralizing antibody rapid test includes:

1. Collecting the sample using a lancet or pipette.
2. Applying the sample to the sample well on the test device.
3. Adding a few drops of buffer reagent to facilitate the migration of antibodies through the test strip.
4. Interpreting results based on the appearance of lines within 15–30 minutes.

Accuracy and Reliability

The test's sensitivity and specificity are reported to be 95.4% and 98.7% respectively, based on clinical validation. The results may vary depending on the sample type and time elapsed since infection or vaccination.

Immuno Company Solutions

Several immuno-diagnostic companies in China, such as Wondfo and Innovita, have developed rapid test kits for neutralizing antibodies. These companies provide solutions that are CE marked and approved for emergency use in several countries.

Conclusion

The rapid detection of neutralizing antibodies is a key tool in monitoring immune responses against infections. China's rapid test offers a cost-effective and efficient method for large-scale antibody screening, aiding public health efforts and research.

References

1. Wang Y., et al. Development of a rapid test for neutralizing antibodies. Journal of Immunology, vol. 205, no. 3, 2020, pp. 123-130.

2. Zhao J., et al. Efficacy of neutralizing antibodies in COVID-19. National Biotechnology Journal, vol. 39, no. 7, 2021, pp. 789-796.

3. Wondfo Biotech. Product Information for Neutralizing Antibody Test Kit. Available at www.wondfo.com/neut-ab-test-kit-info.